circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF609
Synonym: circZNF609
Host Gene: ZNF609
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018874
MONDO name: acute myeloid leukemia
Disease details: acute myeloid leukemia / AML
Disease DO ID:
 9119
Disease MeSH ID:
 D015470
Disease NCIt ID:
 C3171
Disease ICD11 ID:
 -
Disease OMIM ID:
 601626
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MOLM-13; MR-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Bortezomib-responsive, oxidative-stress-dependent hypermethylated circRNA in AML cells.
Molecular mechanism: Hypermethylated (m6A) and upregulated upon bortezomib treatment; induction depends on oxidative stress (blocked by NAC).
Biological pathway or process:

m6A modification (other)
Detected method:
Q
S
Validation methods:

circRNA-seq; RNase R Treatment; RT-qPCR; Bioinformatics Analysis
Clinical significance:

-
Description:

circZNF609 is a bortezomib-inducible, m6A-hypermethylated circRNA in AML cells, and its induction is blocked by antioxidant NAC, linking its upregulation to oxidative stress during proteotoxic stress response.
Confidence score:

0.4276
Other information
Title:

WTAP and m6A-modified circRNAs modulation during stress response in acute myeloid leukemia progenitor cells.

Journal: Cellular and molecular life sciences : CMLS
Published: 2024
PubMed ID: 38909325
Study type:

biological research
Data availability: GSE262829
Code availability: GSE262829