| Expression pattern: |
UP |
| Associated gene: |
XBP1s, BiP, FLT3 |
| Associated microRNA: |
- |
| Biological function: |
Alleviates oxidative and ER stress; protects against misfolded protein accumulation; modulates secretory pathway/stress sensitivity. |
| Molecular mechanism: |
Bortezomib-induced oxidative stress increases m6A methylation (hypermethylation) of circHIPK3 and upregulates its expression; circHIPK3 depletion increases ROS and ER stress markers/aggregates. |
| Biological pathway or process: |
oxidative phosphorylation (other); mitochondrial function (other); other pathway/process (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; Flow Cytometry（Non-apoptosis/cycle）; Western Blot; IF (Immunofluorescence) |
| Clinical significance: |
- |
| Description: |
In MOLM-13 AML cells, bortezomib-induced oxidative stress increases m6A methylation and expression of circHIPK3. circHIPK3 knockdown elevates ROS and exacerbates ER stress/misfolded protein accumulation, indicating a protective role in oxidative and ER stress adaptation. |
| Confidence score: |
0.6772 |