circRNA basic information
circBase ID: hsa_circ_0008360
Name: hsa_circ_XPNPEP3
Synonym: -
Host Gene: XPNPEP3
Genomic location(hg19): chr22:41277773-41278181:+
Genomic location(hg38): chr22:40881769-40882177:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005015
MONDO name: diabetes mellitus
Disease details: diabetes-associated endothelial dysfunction
Disease DO ID:
 9351
Disease MeSH ID:
 D003920
Disease NCIt ID:
 C2985
Disease ICD11 ID:
 465177735
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HUVECs
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-7107-3p, hsa-miR-6753-3p, hsa-miR-18a-3p, hsa-miR-6754-5p, hsa-miR-186-3p
Biological function: unknown
Molecular mechanism: predicted miRNA sponge (ceRNA-like)
Biological pathway or process:

ceRNA regulation (other); proliferation (other); apoptosis (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0008360 is up-regulated in high glucose-induced HUVECs and is bioinformatically predicted to sponge several miRNAs (including hsa-miR-186-3p), suggesting a potential ceRNA-like regulatory role in endothelial dysfunction/angiogenesis-related gene regulation, but downstream targets and functions were not experimentally validated.
Confidence score:

0.2465
Other information
Title:

Profiling and functional analysis of differentially expressed circular RNAs in high glucose-induced human umbilical vein endothelial cells.

Journal: FEBS open bio
Published: 2019
PubMed ID: 31369204
Study type:

biological research
Data availability: available from the corresponding author on reasonable request
Code availability: -