circRNA basic information
circBase ID: -
Name: hsa_circ_CK1gamma3
Synonym: circCK1gamma3
Host Gene: CK1gamma3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; adjacent non-cancerous tissues; plasma; peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Cohort Study; Bioinformatics Analysis
Clinical significance:

Low expression of circCK1gamma3 is associated with lower overall survival; circCK1gamma3 combined with circWDR37 improves CRC screening AUC.
Description:

circCK1gamma3 is down-regulated in CRC tissues and in plasma (including early-stage CRC), and its low expression is associated with worse overall survival. Together with circWDR37, it serves as a combined plasma biomarker panel that improves CRC screening performance.
Confidence score:

0.6759
Other information
Title:

Single-Droplet Dual-Target Quantification of circRNA Biomarkers for Colorectal Cancer Screening.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Published: 2025
PubMed ID: 40583153
Study type:

combined biological and clinical study
Data availability: supplementary material of this article
Code availability: -