| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Hsa_circ_0001649 acts as a tumor suppressor in PDAC; overexpression reduces cell proliferation and colony-forming ability and promotes apoptosis. |
| Molecular mechanism: |
Overexpression of hsa_circ_0001649 suppresses proliferation and colony formation and facilitates apoptosis, with increased caspase-3 and caspase-9 activity; other mechanisms were not explored sufficiently. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry |
| Clinical significance: |
Downregulation of hsa_circ_0001649 was correlated with tumor stage and differentiation grade; hsa_circ_0001649 could serve as an independent prognostic indicator for overall survival in patients with PDAC, and high expression was associated with better 5-year overall survival. |
| Description: |
This study found that hsa_circ_0001649 is down-regulated in PDAC tissues and cell lines. Higher hsa_circ_0001649 expression predicts better overall survival and serves as an independent prognostic indicator. Functionally, hsa_circ_0001649 overexpression suppresses PDAC cell proliferation and colony formation while promoting apoptosis, potentially involving caspase-3 and caspase-9 activation. |
| Confidence score: |
0.6527 |