| Expression pattern: |
UP |
| Associated gene: |
FOXQ1 |
| Associated microRNA: |
miR-140-3p |
| Biological function: |
promotes HCC cell proliferation and tumor growth; acts as a cancer-promoting gene; high expression is associated with tumor size and inferior prognosis |
| Molecular mechanism: |
circ_0001687 acts as a ceRNA to sponge miR-140-3p, relieving miR-140-3p-mediated inhibition of FOXQ1 and increasing FOXQ1 expression |
| Biological pathway or process: |
proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; RNase R Treatment; Actinomycin D / DRB Stability Assay; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Cohort Study |
| Clinical significance: |
high circ_0001687 levels in HCC are associated with worse prognosis; circ_0001687 expression could serve as an independent risk factor for OS and RFS of HCC patients |
| Description: |
circ_0001687 is up-regulated in HCC tissues and its high expression is associated with larger tumor size and poorer OS/RFS. Functionally, circ_0001687 promotes HCC cell proliferation and xenograft tumor growth. Mechanistically, cytoplasmic circ_0001687 functions as a ceRNA for miR-140-3p, thereby increasing FOXQ1 expression. |
| Confidence score: |
0.8548 |