circRNA basic information
circBase ID: hsa_circ_0021509
Name: hsa_circ_ANO5
Synonym: -
Host Gene: ANO5
Genomic location(hg19): chr11:22242642-22279300:+
Genomic location(hg38): chr11:22221096-22257754:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005010
MONDO name: coronary artery disorder
Disease details: coronary artery disease / CAD
Disease DO ID:
 3393
Disease MeSH ID:
 D003324
Disease NCIt ID:
 C26732
Disease ICD11 ID:
 1059873720
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood / peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ANO5
Associated microRNA: -
Biological function: Serves as a circulating diagnostic biomarker and independent predictor for CAD.
Molecular mechanism: Predicted circRNA-miRNA-mRNA (ceRNA) network; enrichment in PI3K/Akt and MAPK signaling pathways.
Biological pathway or process:

PI3K/AKT (other); MAPK (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Cohort Study; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Highly expressed in blood samples of CAD patients; independent predictor of CAD; AUC 0.717.
Description:

hsa_circ_0021509 is up-regulated in peripheral blood of CAD patients and independently associated with CAD, with diagnostic performance (AUC 0.717). Bioinformatic prediction indicates a circRNA-miRNA-mRNA network enriched in PI3K/Akt and MAPK-related signaling.
Confidence score:

0.5534
Other information
Title:

Identification and verification of circRNA biomarkers for coronary artery disease based on WGCNA and the LASSO algorithm.

Journal: BMC cardiovascular disorders
Published: 2024
PubMed ID: 38880872
Study type:

combined biological and clinical study
Data availability: GSE115733
Code availability: -