| Expression pattern: |
UP |
| Associated gene: |
FOXP1 |
| Associated microRNA: |
- |
| Biological function: |
Potential biomarker for treatment follow-up/response; reported in cited studies to inhibit growth and invasion of lung cancer cells when overexpressed. |
| Molecular mechanism: |
Not specified; functional prediction indicates involvement in cancer-related signaling (PI3K-AKT, FOXO) by KEGG analysis. |
| Biological pathway or process: |
PI3K/AKT (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; RT-qPCR; Bioinformatics Analysis |
| Clinical significance: |
Identified as a potential biomarker candidate for treatment follow-up and management in lung cancer. |
| Description: |
In A549 NSCLC cells, hsa_circ_0001320 is absent without treatment but becomes induced after carboplatin and/or pemetrexed, with a synergistic increase under combination therapy. The study proposes it as a candidate biomarker for monitoring chemotherapy response; bioinformatics analyses further suggest pathway involvement (e.g., PI3K-AKT/FOXO) without defining a direct mechanistic axis. |
| Confidence score: |
0.329 |