| Expression pattern: |
UP |
| Associated gene: |
S100A9, MID1, DHX9 |
| Associated microRNA: |
miR-506-3p |
| Biological function: |
Promotes prostate cancer/CRPC cell proliferation, migration, and invasion; facilitates tumor growth in vivo in the context of MDSC-derived exosomes. |
| Molecular mechanism: |
Exosomal S100A9 upregulates circMID1 (partly via inhibiting DHX9); circMID1 acts as a ceRNA/miRNA sponge for miR-506-3p, resulting in increased MID1 expression and enhanced CRPC progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
High circMID1 expression was found in PCa vs BPH tissues and in CRPC vs HSPC patients. |
| Description: |
circMID1 (hsa_circ_0007718), derived from MID1, is up-regulated in prostate cancer and further elevated in CRPC and in PCa cells treated with MDSC-derived exosomes. It promotes proliferation, migration, invasion, and xenograft growth by sponging miR-506-3p to increase MID1 expression, forming a S100A9/circMID1/miR-506-3p/MID1 regulatory axis. |
| Confidence score: |
0.8162 |