circRNA basic information
circBase ID: hsa_circ_0000615
Name: hsa_circ_ZNF609
Synonym: circZNF609 / circ0000615
Host Gene: ZNF609
Genomic location(hg19): chr15:64791491-64792365:+
Genomic location(hg38): chr15:64499292-64500166:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018177
MONDO name: glioblastoma
Disease details: glioblastoma / GBM
Disease DO ID:
 3068
Disease MeSH ID:
 D005909
Disease NCIt ID:
 C3058
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; normal brain tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: EGFR
Associated microRNA: miR-145-5p
Biological function: May contribute to glioblastoma pathogenesis and may regulate EGFR expression via sponging miR-145-5p.
Molecular mechanism: Putative ceRNA mechanism: circZNF609 sponges miR-145-5p, associated with EGFR upregulation.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

cZNF609 can serve as good predictive biomarker to distinguish malignant from non-malignant tissues.
Description:

circZNF609 (hsa_circ_0000615, from ZNF609) is significantly upregulated in glioblastoma tissues versus normal brain. The study proposes a ceRNA model in which circZNF609 sponges miR-145-5p, consistent with inverse correlation to miR-145-5p and positive correlation with EGFR, suggesting potential involvement in GBM pathogenesis and diagnostic discrimination.
Confidence score:

0.6238
Other information
Title:

CircZNF609 and circNFIX as possible regulators of glioblastoma pathogenesis via miR-145-5p/EGFR axis.

Journal: Scientific reports
Published: 2024
PubMed ID: 38866807
Study type:

combined biological and clinical study
Data availability: GSE165937
Code availability: -