| Expression pattern: |
UP |
| Associated gene: |
EZH2, p53, H3K27me3 |
| Associated microRNA: |
- |
| Biological function: |
CircAGFG1 promotes cervical cancer progression and proliferation; knockdown of circAGFG1 suppresses the proliferative ability of CC cells. |
| Molecular mechanism: |
CircAGFG1 recruits EZH2 to suppress p53 transcription, thereby promoting cervical cancer proliferation and progression. |
| Biological pathway or process: |
proliferation (promotes); p53 signaling (inhibits); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); ChIP / ChIP-seq; Western Blot; Survival Analysis; Cohort Study |
| Clinical significance: |
CircAGFG1 level is associated with worse tumor staging, higher metastasis rate, larger tumor size, and worse prognosis in CC patients. |
| Description: |
CircAGFG1 is upregulated in cervical cancer tissues and cell lines and is associated with advanced malignant features and poor prognosis. Functionally, circAGFG1 promotes CC cell proliferation and disease progression by recruiting EZH2 to suppress p53 transcription. |
| Confidence score: |
0.7789 |