| Expression pattern: |
UP |
| Associated gene: |
EIF4A3, PHEX |
| Associated microRNA: |
- |
| Biological function: |
Promotes gastric cancer cell proliferation, migration, invasion and tumorigenesis; EV-delivered hsa_circ_0090081 facilitates malignant progression of recipient GC cells. |
| Molecular mechanism: |
EIF4A3 (RBP) binds PHEX pre-mRNA and positively regulates hsa_circ_0090081 biogenesis/expression; hsa_circ_0090081 is packaged into extracellular vesicles and transferred to target GC cells to enhance malignant phenotypes. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (not specified) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; EdU Staining; Transwell Assay; RIP (RNA Immunoprecipitation); Western Blot; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Upregulation of hsa_circ_0090081 predicts decreased survival time in patients with GC. |
| Description: |
hsa_circ_0090081 is up-regulated in gastric cancer and promotes proliferation, migration and invasion of GC cells. EIF4A3 binds PHEX pre-mRNA and increases hsa_circ_0090081 expression, and GC cell-derived extracellular vesicles deliver hsa_circ_0090081 to recipient cells to enhance tumorigenic phenotypes. High hsa_circ_0090081 expression is associated with poorer patient survival. |
| Confidence score: |
0.7941 |