| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
microRNA-432, miR-432 |
| Biological function: |
CircSOX4 promotes HCC cell proliferation, migration and invasion, inhibits apoptosis, and may serve as an oncogene in HCC progression. |
| Molecular mechanism: |
CircSOX4 binds to microRNA-432 and negatively regulates microRNA-432 expression; microRNA-432 inhibition partially reverses the effects of circSOX4 knockdown on proliferation, migration, invasion and apoptosis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High expression of circSOX4 indicates poor prognosis in HCC patients. |
| Description: |
CircSOX4 is up-regulated in HCC tissues and cell lines, and high circSOX4 expression is associated with poor prognosis. Functionally, circSOX4 promotes HCC cell proliferation, migration and invasion while suppressing apoptosis, likely through binding to and negatively regulating microRNA-432. |
| Confidence score: |
0.7113 |