| Expression pattern: |
DN |
| Associated gene: |
EPHA4, KCNA1, NCAM1 |
| Associated microRNA: |
hsa-miR-615-5p, hsa-miR-767-5p |
| Biological function: |
Suppresses the migration and invasion ability of gastric cancer cells. |
| Molecular mechanism: |
hsa_circ_0002504 may inhibit gastric cancer progression via a ceRNA network by down-regulating hsa-miR-615-5p and hsa-miR-767-5p and up-regulating EPHA4, KCNA1, and NCAM1. |
| Biological pathway or process: |
ceRNA regulation (other); migration (inhibits); invasion (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Transfection; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Hsa_circ_0002504 is a potential diagnostic biomarker for GC. |
| Description: |
hsa_circ_0002504 was down-regulated in gastric cancer datasets and cell lines and was experimentally validated by qRT-PCR. Its overexpression reduced migration and invasion of AGS and HGC-27 cells, possibly through a ceRNA mechanism involving hsa-miR-615-5p/hsa-miR-767-5p and EPHA4, KCNA1, and NCAM1. The study proposes hsa_circ_0002504 as a potential diagnostic biomarker and therapeutic target for GC. |
| Confidence score: |
0.4852 |