| Expression pattern: |
DN |
| Associated gene: |
AGO2, SOX6, AKT, Bcl-2 |
| Associated microRNA: |
miR-330-3p |
| Biological function: |
inhibits proliferation; inhibits migration; inhibits invasion; inhibits tumor growth in vivo |
| Molecular mechanism: |
circCPNE1 acts as a miRNA sponge for miR-330-3p, regulating downstream SOX6 expression and related proteins (AKT, Bcl-2). |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; FISH / smFISH; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); TUNEL; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
circCPNE1 expression level was negatively correlated with the clinical stage of OSCC patients. |
| Description: |
circCPNE1 (hsa_circ_0001146) is down-regulated in OSCC tissues and cell lines and is negatively associated with clinical stage. Functionally, circCPNE1 suppresses OSCC proliferation, migration, invasion and xenograft growth by acting as a cytoplasmic miR-330-3p sponge, thereby relieving repression of SOX6 and affecting AKT/Bcl-2 levels. |
| Confidence score: |
0.8254 |