circRNA basic information
circBase ID: hsa_circ_0073966
Name: hsa_circ_SEC24A
Synonym: circSEC24A / circRNA SEC24A
Host Gene: SEC24A
Genomic location(hg19): chr5:134002512-134063601:+
Genomic location(hg38): chr5:134666822-134727911:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005178
MONDO name: osteoarthritis
Disease details: Osteoarthritis / OA
Disease DO ID:
 8398
Disease MeSH ID:
 D010003
Disease NCIt ID:
 C3293
Disease ICD11 ID:
 558562409
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

rat cartilage tissues / OA cartilage tissues; human articular cartilages of knees
Cell lines:

293T
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: CASP3
Associated microRNA: miR-107-5p
Biological function: promotes OA progression by inhibiting chondrocyte proliferation and promoting chondrocyte apoptosis, ECM degradation and inflammation
Molecular mechanism: acts as a ceRNA/miRNA sponge for miR-107-5p to upregulate CASP3
Biological pathway or process:

proliferation (inhibits); apoptosis (promotes); inflammation (promotes); fibrosis (not specified); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Transfection; MTT; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; ELISA; In Vivo Animal Model; H&E Staining; TUNEL
Clinical significance:

-
Description:

circSEC24A is up-regulated in OA cartilage and IL-1beta-stimulated chondrocytes and promotes OA progression. Mechanistically, it sponges miR-107-5p to derepress CASP3, thereby increasing chondrocyte apoptosis and enhancing ECM degradation and inflammatory cytokine changes; circSEC24A silencing alleviates OA in an ACLT rat model.
Confidence score:

0.674
Other information
Title:

CircRNA SEC24A promotes osteoarthritis through miR-107-5p/CASP3 axis.

Journal: Regenerative therapy
Published: 2024
PubMed ID: 38828010
Study type:

combined biological and clinical study
Data availability: Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.
Code availability: -