| Expression pattern: |
UP |
| Associated gene: |
BARD1 |
| Associated microRNA: |
miR-3942-3p |
| Biological function: |
circRNA_BARD1 up-regulation induced by TCDD inhibits cell proliferation, arrests cell cycle in G0/G1 phase, facilitates apoptosis, promotes DNA lesion, and suppresses tumor growth and metastasis in breast cancer models. |
| Molecular mechanism: |
TCDD induces circRNA_BARD1 overexpression; circRNA_BARD1 reversely regulates miR-3942-3p and positively regulates BARD1, consistent with an endogenous competition/ceRNA mechanism through the circRNA_BARD1/miR-3942-3p/BARD1 axis. |
| Biological pathway or process: |
apoptosis (promotes); proliferation (inhibits); cell cycle (inhibits); metastasis (inhibits); ceRNA regulation (other); p53 signaling (promotes); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; IF (Immunofluorescence); In Vivo Animal Model |
| Clinical significance: |
TCDD/cricRNA_BARD1/miR-3942-3p/BARD1 axis could be a novel regulator in the therapy of breast cancer. |
| Description: |
Hsa_circ_0001098/circRNA_BARD1 is up-regulated in TCDD-treated breast cancer samples and MCF-7 cells. Its overexpression suppresses proliferation, arrests the cell cycle, promotes apoptosis, and inhibits xenograft tumor growth and metastasis, at least partly through the miR-3942-3p/BARD1 regulatory axis. |
| Confidence score: |
0.6835 |