circRNA basic information
circBase ID: -
Name: hsa_circ_MTO1
Synonym: circMTO1
Host Gene: MTO1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

clinical breast tissue specimens; healthy para-carcinoma tissues; breast cancer tissues
Cell lines:

A549; HeLa; MCF-7; L02; MCF-10A; HepG2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: circMTO1 is downregulated in breast cancer tissues and can serve as a diagnostic marker to distinguish breast cancer tissues from healthy counterparts.
Molecular mechanism: -
Biological pathway or process:

not specified (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

circMTO1 measurement by the single QD-based FRET nanosensor can differentiate breast cancer tissues from healthy tissues with AUC = 1.
Description:

This study used circMTO1 as the target circRNA for a single quantum dot-based FRET nanosensor and showed that circMTO1 expression is lower in breast cancer tissues than in healthy para-carcinoma tissues. The assay results were consistent with qRT-PCR and achieved ROC AUC = 1 for distinguishing breast cancer tissues from healthy counterparts, supporting circMTO1 monitoring as a potential diagnostic application.
Confidence score:

0.4187
Other information
Title:

Construction of a multilayer fluorescence-encoded single quantum dot-based FRET nanosensor for simple and sensitive monitoring of circular RNA in clinical tissues.

Journal: Biosensors & bioelectronics
Published: 2026
PubMed ID: 41538967
Study type:

combined methodological and clinical diagnostic study
Data availability: Data will be made available on request; https://doi. org/10.1016/j.bios.2026.118401
Code availability: -