| Expression pattern: |
UP |
| Associated gene: |
G protein regulated inducer of neurite outgrowth 1 (GPRIN1), Ago2 |
| Associated microRNA: |
miR-585-3p |
| Biological function: |
promotes Taxol resistance, proliferation, motility and invasiveness; inhibits apoptosis |
| Molecular mechanism: |
ceRNA sponging of miR-585-3p to modulate GPRIN1 |
| Biological pathway or process: |
chemoresistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
circ_0002360 expression was correlated with tumor size, differentiation, and lymphatic metastasis of the tumors |
| Description: |
circ_0002360 is up-regulated in Taxol-resistant NSCLC and mainly localized in the cytoplasm. It promotes Taxol resistance and malignant behaviors (proliferation, migration/invasion) and suppresses apoptosis by sponging miR-585-3p to increase GPRIN1 expression, and circ_0002360 knockdown sensitizes tumors to Taxol in a xenograft model. |
| Confidence score: |
0.8443 |