| Expression pattern: |
UP |
| Associated gene: |
CCNB1 |
| Associated microRNA: |
miR-622 |
| Biological function: |
promotes metastasis/migration/invasion and promotes in vivo tumor growth/proliferation in HCC; knockdown suppresses MMP-2 and MMP-9 activities |
| Molecular mechanism: |
ceRNA (miRNA sponge): circ-0006091 sponges miR-622 to regulate CCNB1 expression, affecting metastasis-related phenotypes |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes); proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Transfection; Wound Healing Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model |
| Clinical significance: |
circ-0006091 was upregulated in HCC tumor tissues relative to normal tissues |
| Description: |
circ-0006091 is up-regulated in HCC tissues and HCC cell lines and promotes migration/invasion and in vivo tumor growth. Mechanistically, it functions as a miRNA sponge for miR-622 to increase CCNB1 expression, forming a circ-0006091/miR-622/CCNB1 regulatory axis. |
| Confidence score: |
0.74 |