circRNA basic information
circBase ID: -
Name: hsa_circ_BIRC6
Synonym: circBIRC6
Host Gene: BIRC6
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid carcinoma / PTC
Disease DO ID:
3969
Disease MeSH ID:
-
Disease NCIt ID:
C4035
Disease ICD11 ID:
-
Disease OMIM ID:
-
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum exosomes

Cell lines:

Nthy-ori 3-1; BCPAP

In vivo animal model:

-

circRNA-disease information
Expression pattern:
DN
Associated gene: BCL2L11
Associated microRNA: miR-24-3p
Biological function: potentially facilitates PTC progression via apoptosis-related tumor suppressor BCL2L11
Molecular mechanism: ceRNA mechanism involving miR-24-3p and BCL2L11
Biological pathway or process:

apoptosis (other); ceRNA regulation (other)

Detected method:
Q
S
Validation methods:

circRNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis

Clinical significance:

potential as biomarkers in PTC patients with LNM

Description:

This study found exosomal circBIRC6 is down-regulated in PTC with lymph node metastasis and preliminarily validated its expression by RT-qPCR. The proposed mechanism is a ceRNA axis where circBIRC6 regulates miR-24-3p and the apoptosis-related gene BCL2L11, potentially contributing to PTC progression and metastasis.

Confidence score:

0.4685

Other information
Title:

Expression profiling and bioinformatics analysis of serum exosomal circular RNAs in lymph node metastasis of papillary thyroid carcinoma.

Journal: Journal of biomedical research
Published: 2024
PubMed ID: 38812291
Study type:

combined biological and clinical study

Data availability: GSE247120
Code availability: -