| Expression pattern: |
DN |
| Associated gene: |
HNRNPA1, HNRNPM, eIF4A3, PTBP1, ELAVL1, HNRNPD, AGO2 |
| Associated microRNA: |
- |
| Biological function: |
Acts as a protein sponge inhibiting RNA splicing-associated RBPs (notably HNRNPA1); reduced circHIBADH is linked to enhanced carcinogenesis-related programs. |
| Molecular mechanism: |
rs11973492 may reduce circHIBADH generation by altering RNA secondary structure; circHIBADH sponges RBPs including HNRNPA1 to inhibit RNA splicing, influencing downstream oncogenic hallmarks. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); cell cycle (promotes); other pathway/process (other) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; Cohort Study |
| Clinical significance: |
rs11973492 in circHIBADH was significantly associated with increased prostate cancer risk (dominant model). |
| Description: |
circHIBADH is down-regulated in prostate cancer tumors versus adjacent normal tissue and is proposed to function as a protein sponge for RNA splicing-associated RBPs, especially HNRNPA1. The risk variant rs11973492 may reduce circHIBADH biogenesis by altering RNA secondary structure, weakening RBP sponging and thereby facilitating RNA-splicing-linked carcinogenic programs (e.g., MYC target, DNA repair, E2F target). |
| Confidence score: |
0.348 |