circRNA basic information
circBase ID: hsa_circ_0001671
Name: hsa_circ_EIF3B
Synonym: circ_0001671
Host Gene: EIF3B
Genomic location(hg19): chr7:2404006-2406083:+
Genomic location(hg38): chr7:2364371-2366448:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer / PCa
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PCa tumor tissues; adjacent non-tumor tissues; mouse tumor tissues
Cell lines:

PC3; 22RV1; LNCaP; RWPE-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: BLM, Ago2
Associated microRNA: miR-27b-3p
Biological function: Promotes proliferation, migration, and invasion; inhibits apoptosis; facilitates tumor growth in vivo.
Molecular mechanism: Acts as a competing endogenous RNA (ceRNA) that sponges miR-27b-3p to upregulate BLM.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Wound Healing Assay; Western Blot; IF (Immunofluorescence); In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

circ_0001671 holds promise as both a diagnostic biomarker and a therapeutic target for prostate cancer.
Description:

hsa_circ_0001671 (circ_0001671), derived from EIF3B, is up-regulated in prostate cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes proliferation, migration, invasion and tumor growth while inhibiting apoptosis by sponging miR-27b-3p to upregulate BLM (circ_0001671/miR-27b-3p/BLM ceRNA axis).
Confidence score:

0.8748
Other information
Title:

Circ_0001671 regulates prostate cancer progression through miR-27b-3p/BLM axis.

Journal: Scientific reports
Published: 2024
PubMed ID: 38806577
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analysed during the current study available from the corresponding author on reasonable request.
Code availability: -