| Expression pattern: |
UP |
| Associated gene: |
FZD3, Wnt/b-catenin pathway |
| Associated microRNA: |
miR-607 |
| Biological function: |
circ-CBFB promotes CLL cell proliferation and cell cycle progression, inhibits apoptosis, and serves as a diagnostic and prognostic biomarker. |
| Molecular mechanism: |
circ-CBFB acts as a ceRNA sponge for miR-607, increases FZD3 expression, and activates the Wnt/b-catenin pathway to promote CLL progression. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; Cohort Study |
| Clinical significance: |
circ-CBFB expression could distinguish CLL patients from normal controls, and higher circ-CBFB expression predicted lower survival time and was an independent predictor of prognosis. |
| Description: |
circ-CBFB is upregulated in CLL cells and functions as an oncogenic circRNA. It promotes proliferation and cell cycle progression while inhibiting apoptosis through the miR-607/FZD3/Wnt/b-catenin axis, and its high expression is associated with diagnostic value and poorer survival in CLL patients. |
| Confidence score: |
0.7513 |