circRNA basic information
circBase ID: -
Name: hsa_circ_PLXDC2
Synonym: circPLXDC2
Host Gene: PLXDC2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: extracellular vesicle
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: high-grade prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

urine extracellular vesicles
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Diagnostic biomarker component of the urine extracellular vesicle circRNA classifier (Ccirc) for detecting ≥GG2 prostate cancer.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Cohort Study; ROC Analysis; ddPCR
Clinical significance:

Included in Ccirc, which shows higher accuracy than standard risk calculators and improves prediction of ≥GG2 PCa.
Description:

circPLXDC2 is elevated in urine extracellular vesicles from high-grade (≥GG2) prostate cancer patients and is a component of the Ccirc diagnostic signature. It contributes to improved noninvasive prediction of clinically significant PCa compared with standard risk calculators.
Confidence score:

0.5414
Other information
Title:

A urine extracellular vesicle circRNA classifier for detection of high-grade prostate cancer in patients with prostate-specific antigen 2-10 ng/mL at initial biopsy.

Journal: Molecular cancer
Published: 2021
PubMed ID: 34301266
Study type:

combined biological and clinical study
Data availability: GSE147761
Code availability: -