circRNA basic information
circBase ID: hsa_circ_0049271
Name: hsa_circ_KEAP1
Synonym: -
Host Gene: KEAP1
Genomic location(hg19): chr19:10610070-10610756:-
Genomic location(hg38): chr19:10499394-10500080:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LUAD tissues; normal tissues
Cell lines:

BEAS-2B; A549; HCC827; H1299; PC-9; 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: DCN
Associated microRNA: hsa-miR-224-5p
Biological function: May act as a tumor-suppressive circRNA in LUAD by affecting DCN expression via sponging miR-224-5p, and may relate to prognosis and immune modulation.
Molecular mechanism: ceRNA mechanism: hsa_circ_0049271 sponges hsa-miR-224-5p to regulate DCN.
Biological pathway or process:

ceRNA regulation (other); immune regulation (other); prognosis (other)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; Transfection; Luciferase Reporter Assay
Clinical significance:

Might impact initiation, prognosis, and immune modulation of LUAD via the hsa_circ_0049271/hsa-miR-224-5p/DCN axis.
Description:

In LUAD, hsa_circ_0049271 is down-regulated and participates in a ceRNA axis where it binds hsa-miR-224-5p to influence DCN expression. The axis is suggested to impact tumor initiation, prognosis and immune modulation, supported by qPCR, luciferase assays, and circRNA overexpression with rescue by miRNA mimic.
Confidence score:

0.4851
Other information
Title:

Integrated analysis reveals key circRNA-mediated regulatory axes related to prognosis and immune infiltration in lung adenocarcinoma.

Journal: BMC medical genomics
Published: 2025
PubMed ID: 40640792
Study type:

combined biological and clinical study
Data availability: GSE101586; GSE101684; GSE68465; TCGA-LUAD
Code availability: -