| Expression pattern: |
DN |
| Associated gene: |
RORC |
| Associated microRNA: |
hsa-miR-1248 |
| Biological function: |
Potential diagnostic biomarker for COPD; may regulate COPD pathogenesis via a ceRNA network affecting inflammatory response. |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0000673 directly binds (sponges) hsa-miR-1248 and is linked to downstream target RORC. |
| Biological pathway or process: |
ceRNA regulation (other); inflammation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; RNase R Treatment; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
A combination of hsa_circ_0067209 and hsa_circ_0000673 showed diagnostic value for COPD (AUC = 0.866); hsa_circ_0000673 expression was significantly related to FEV1/FVC%. |
| Description: |
hsa_circ_0000673 is down-regulated in PBMCs from COPD patients and contributes to a diagnostic signature when combined with hsa_circ_0067209. It directly binds hsa-miR-1248 and is linked to the downstream target RORC, forming a ceRNA axis suggested to influence COPD progression by regulating inflammatory responses. |
| Confidence score: |
0.6034 |