circRNA basic information
circBase ID: -
Name: hsa_circ_ISPD
Synonym: circISPD
Host Gene: ISPD
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0003210
MONDO name: intrahepatic cholangiocarcinoma
Disease details: intrahepatic cholangiocarcinoma
Disease DO ID:
 4928
Disease MeSH ID:
 -
Disease NCIt ID:
 C35417
Disease ICD11 ID:
 1253728223; 387909164
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

ICC frozen tumor specimens; frozen tumor tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; circRNA-seq; RT-qPCR; Clinical Sample Validation; Survival Analysis
Clinical significance:

circISPD was significantly higher in tumors from patients without postoperative recurrence, but survival outcomes were not associated with circISPD
Description:

circISPD was identified by circRNA-seq as one of the circRNAs most highly expressed in ICC tumors from patients without postoperative recurrence and was validated by qRT-PCR as significantly higher in non-recurrent tumors. The study did not report a survival association or functional mechanism for circISPD.
Confidence score:

0.6428
Other information
Title:

A novel protein encoded by circFOXP1 enhances ferroptosis and inhibits tumor recurrence in intrahepatic cholangiocarcinoma.

Journal: Cancer letters
Published: 2024
PubMed ID: 38945202
Study type:

combined bioinformatics and clinical study
Data availability: Supplementary data online at https://doi.org/10.1016/j.canlet.2024.217092
Code availability: -