circRNA basic information
circBase ID: hsa_circ_0001658
Name: -
Synonym: circ0001658
Host Gene: -
Genomic location(hg19): chr6:157357968-157406039:+
Genomic location(hg38): chr6:157036834-157084905:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric cancer tissues; normal tissues; matched non-tumor tissues; adjacent tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PAX6
Associated microRNA: hsa-miR-375
Biological function: hsa_circ_0001658 was significantly downregulated in gastric cancer and was proposed as part of a circ0001658-miR-375-PAX6 regulatory network that may modulate GC and serve as a potential biomarker.
Molecular mechanism: Potential ceRNA-like circRNA-miRNA-mRNA regulatory mechanism involving hsa_circ_0001658, hsa-miR-375 and PAX6, inferred from microarray data and CircInteractome/TargetScan bioinformatics analysis.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

These 3 circRNAs may be potential biomarkers in GC.
Description:

hsa_circ_0001658 was identified by GEO circRNA microarray analysis as significantly downregulated in gastric cancer versus controls. Bioinformatics analysis suggested that it is related to hsa-miR-375 and may participate in a circ0001658-miR-375-PAX6 regulatory axis with potential biomarker relevance in GC.
Confidence score:

0.1768
Other information
Title:

miRNA and mRNA expression profiles in gastric cancer patients and the relationship with circRNA.

Journal: Neoplasma
Published: 2019
PubMed ID: 31307199
Study type:

bioinformatics study
Data availability: GSE78092
Code availability: -