circRNA basic information
circBase ID: hsa_circ_0026239
Name: hsa_circ_LARP4
Synonym: -
Host Gene: LARP4
Genomic location(hg19): chr12:50847242-50860903:+
Genomic location(hg38): chr12:50453459-50467120:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005148
MONDO name: type 2 diabetes mellitus
Disease details: type 2 diabetes mellitus / T2DM
Disease DO ID:
 9352
Disease MeSH ID:
 D003924
Disease NCIt ID:
 C26747
Disease ICD11 ID:
 119724091
Disease OMIM ID:
 125853
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TM4SF1
Associated microRNA: hsa-mir-4310
Biological function: Implicated as an up-regulated circRNA marker in F-T2DM and included in an up-regulated ceRNA axis targeting TM4SF1.
Molecular mechanism: ceRNA mechanism (predicted/constructed): hsa_circ_0026239—hsa-mir-4310—TM4SF1.
Biological pathway or process:

ceRNA regulation (promotes)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

May serve as a specific molecular marker for F-T2DM.
Description:

hsa_circ_0026239 is up-regulated in F-T2DM relative to both controls and NF-T2DM. It is included in an up-regulated ceRNA axis (hsa_circ_0026239/hsa-mir-4310/TM4SF1) and is proposed as a potential molecular marker for fatigue-type diabetes.
Confidence score:

0.1768
Other information
Title:

The circRNA-mediated ceRNA molecular regulatory network in fatigue-type type 2 diabete.

Journal: Journal of translational medicine
Published: 2025
PubMed ID: 40898233
Study type:

bioinformatics study
Data availability: GSE277813
Code availability: -