| Expression pattern: |
UP |
| Associated gene: |
E-cadherin, vimentin, Snail, Ki-67 |
| Associated microRNA: |
- |
| Biological function: |
Promotes HCC progression by promoting proliferation, migration and invasion, inhibiting apoptosis, and facilitating the epithelial-mesenchymal transition (EMT) process; supports tumor growth in vivo. |
| Molecular mechanism: |
Regulates EMT marker expression (E-cadherin up; vimentin and Snail down) in HCC cells and xenograft tumors; specific upstream ceRNA/protein mechanism not elucidated. |
| Biological pathway or process: |
EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; TUNEL; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
hsa_circ_0051908 expression was significantly correlated with tumor size, tumor differentiation, TNM stage, and lymph node metastasis; suggested as a prognostic indicator and therapeutic target for liver cancer. |
| Description: |
hsa_circ_0051908 is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, migration and invasion, increases apoptosis, and inhibits EMT-associated marker changes (E-cadherin up; vimentin/Snail down), reducing xenograft tumor growth. |
| Confidence score: |
0.622 |