| Expression pattern: |
DN |
| Associated gene: |
AHNAK, TRIM25, TXNIP, AGO2, QKI, TGF-beta/Smad signaling pathway |
| Associated microRNA: |
miR-873-5p |
| Biological function: |
Suppresses NSCLC cell proliferation, migration, invasion, EMT and metastasis; promotes apoptosis; enhances sensitivity to cisplatin and oxaliplatin. |
| Molecular mechanism: |
Binds AHNAK and acts as a scaffold to enhance TRIM25-mediated ubiquitination and proteasomal degradation of AHNAK, inhibiting TGF-beta/Smad signaling and EMT; also functions as a miRNA sponge for miR-873-5p to upregulate TXNIP, contributing to inactivation of TGF-beta/Smad pathway. |
| Biological pathway or process: |
TGF-beta/SMAD (inhibits); EMT (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); apoptosis (promotes); ceRNA regulation (other); ubiquitination (promotes); chemoresistance (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Sanger Sequencing; divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Transfection; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); IF (Immunofluorescence); TUNEL; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low circ6834 levels were related to advanced TNM stage; circ6834 showed diagnostic value (AUC 0.8239); low circ6834 expression was associated with shorter survival time. |
| Description: |
Circ6834 (hsa_circ_0006834), derived from EPB41L5, is down-regulated in NSCLC and functions as a tumor suppressor. It inhibits proliferation, EMT, migration/invasion and metastasis by promoting TRIM25-dependent ubiquitination/degradation of AHNAK and by sponging miR-873-5p to upregulate TXNIP, thereby dampening TGF-beta/Smad signaling; it also increases sensitivity to cisplatin/oxaliplatin. |
| Confidence score: |
0.8933 |