circRNA basic information
circBase ID: hsa_circ_0006461
Name: hsa_circ_KDM4B
Synonym: circKDM4B
Host Gene: KDM4B
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; paired normal tissues; adjacent nontumor tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Expression is significantly increased in HCC tissues compared with adjacent nontumor tissues; no functional role was further characterized in this study.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

circKDM4B was identified from GEO microarray datasets and validated by RT-qPCR as significantly increased in HCC tissues versus adjacent nontumor tissues. The study did not further characterize its function, mechanism, localization, or clinical prognostic value.
Confidence score:

0.4032
Other information
Title:

Circular RNA MAT2B Promotes Glycolysis and Malignancy of Hepatocellular Carcinoma Through the miR-338-3p/PKM2 Axis Under Hypoxic Stress.

Journal: Hepatology (Baltimore, Md.)
Published: 2019
PubMed ID: 31004447
Study type:

bioinformatics study; clinical study
Data availability: GSE97332; GSE94508; GSE78520
Code availability: -