circRNA basic information
circBase ID: hsa_circ_0002360
Name: hsa_circ_RUNX1
Synonym: circRUNX1
Host Gene: RUNX1
Genomic location(hg19): chr21:36206706-36231875:-
Genomic location(hg38): chr21:34834409-34859578:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

formalin-fixed, paraffin-embedded lung tumor samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PHF19
Associated microRNA: has-miR-3620-5p, hsa-miR-1273, hsa-miR-127-5p, hsa-miR-145, hsa-miR-585, hsa-miR-629, hsa-miR-758, hsa-miR-933
Biological function: Serves as a biomarker associated with recurrence and shorter relapse-free/disease-free survival in resected EGFR-mutant NSCLC.
Molecular mechanism: Previously reported/predicted ceRNA interactions: circRUNX1 regulating PHF19 through has-miR-3620-5p; additional miRNAs predicted to bind circRUNX1 by circinteractome.
Biological pathway or process:

not specified
Detected method:
S
Validation methods:

RT-qPCR; Sanger Sequencing; divergent primers PCR; Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis; RNA-seq
Clinical significance:

High circRUNX1 expression is associated with significantly shorter relapse-free survival/DFS and is a prognostic factor for recurrence in EGFR-mutant NSCLC.
Description:

circRUNX1 (hsa_circ_0002360) is up-regulated in tumors from relapsing versus nonrelapsing EGFR-mutant resected NSCLC patients in nCounter analysis and is associated with shorter relapse-free/disease-free survival. It is included in a random-forest-derived 6-circRNA signature predictive of recurrence.
Confidence score:

0.6895
Other information
Title:

Brief Report: circRUNX1 as Potential Biomarker for Cancer Recurrence in EGFR Mutation-Positive Surgically Resected NSCLC.

Journal: JTO clinical and research reports
Published: 2023
PubMed ID: 38162176
Study type:

combined biological and clinical study
Data availability: Supplementary Table 1; Supplementary Methods; Supplementary Tables 6 and 7
Code availability: -