| Expression pattern: |
DN |
| Associated gene: |
BCL11B, P53 |
| Associated microRNA: |
miR-330 |
| Biological function: |
Suppresses proliferation, migration and invasion; induces G1 cell-cycle arrest and promotes apoptosis; inhibits tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-330, releasing BCL11B expression and increasing P53 expression to trigger G1 arrest and apoptosis. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); cell cycle (inhibits); apoptosis (promotes); p53 signaling (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Colony Formation Assay; Wound Healing Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry) |
| Clinical significance: |
circITGA7 was significantly downregulated in HCC tissue compared to adjacent non-tumor tissue and may be a potential biomarker; decreased circITGA7 levels were associated with a worse prognosis in HCC. |
| Description: |
circITGA7 is down-regulated in HCC tissues and cell lines and functions as a tumor suppressor. It sponges miR-330, thereby de-repressing BCL11B and increasing P53 expression, which leads to G1 arrest and apoptosis and suppresses proliferation/migration/invasion and xenograft growth. |
| Confidence score: |
0.7701 |