| Expression pattern: |
UP |
| Associated gene: |
MyD88, NF-kB, ICAM1, VCAM1 |
| Associated microRNA: |
miR-6873-3p, miR-6833-3p |
| Biological function: |
Promotes ox-LDL-induced endothelial inflammatory response; knockdown reduces ICAM1 and VCAM1 expression. |
| Molecular mechanism: |
circ-RELL1 acts as a ceRNA sponge for miR-6873-3p, increasing MyD88-mediated NF-kB activation and inflammatory factor expression. |
| Biological pathway or process: |
NF-kappaB (promotes); inflammation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; FISH / smFISH; Luciferase Reporter Assay; Transfection; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Potential therapeutic candidate for endothelium inflammation in atherosclerotic cardiovascular disease. |
| Description: |
circ-RELL1/hsa_circ_0002194 is up-regulated in ox-LDL-stimulated HUVECs and promotes endothelial inflammation. Mechanistically, it sponges miR-6873-3p in the cytoplasm, thereby increasing MyD88-mediated NF-kB activation and ICAM1/VCAM1 expression. |
| Confidence score: |
0.6491 |