| Expression pattern: |
UP |
| Associated gene: |
IFN-gamma, TNF-alpha |
| Associated microRNA: |
- |
| Biological function: |
Promotes NSCLC cell proliferation, migration and invasion, and facilitates immune escape; its knockdown enhances antitumor immune response (in vitro). |
| Molecular mechanism: |
Immune-escape related regulation affecting cytokine release (IFN-gamma, TNF-alpha) and CIK-mediated cytotoxicity; detailed mechanism not determined. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); immune regulation (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Transfection; CCK8; Transwell Assay; ELISA |
| Clinical significance: |
High serum circPTP4A2 distinguishes NSCLC patients from healthy controls (AUC=0.8996) and has potential diagnostic value. |
| Description: |
circPTP4A2 is up-regulated in NSCLC serum, tumor tissues and cell lines, and shows diagnostic potential (ROC AUC ~0.90). Silencing circPTP4A2 suppresses NSCLC cell proliferation/migration/invasion and enhances antitumor immune responses in co-culture assays, suggesting it promotes immune escape in vitro. |
| Confidence score: |
0.7078 |