circRNA basic information
circBase ID: hsa_circ_0068631
Name: hsa_circ_TFRC
Synonym: circ-TFRC
Host Gene: TFRC
Genomic location(hg19): chr3:195802029-195803993:-
Genomic location(hg38): chr3:196075158-196077122:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008170
MONDO name: ovarian cancer
Disease details: ovarian cancer / OC
Disease DO ID:
 2394
Disease MeSH ID:
 D010051
Disease NCIt ID:
 C7431
Disease ICD11 ID:
 685124533
Disease OMIM ID:
 167000
Species: Human
Species details: Homo sapiens
Tissue specimen:

OC tissues / primary OC; normal tissues
Cell lines:

OVCAR-3; SKOV3; A2780; ES-2; IOSE80; HEK293; HEK293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: IGF2
Associated microRNA: miR-615-3p
Biological function: promotes ovarian cancer cell proliferation, migration, invasion, tumor growth and lung metastasis
Molecular mechanism: circ-TFRC acts as a miR-615-3p sponge to promote IGF2 expression
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
H
Validation methods:

RT-qPCR; FISH / smFISH; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining
Clinical significance:

high circ-TFRC expression indicated a poor prognosis of OC
Description:

circ-TFRC (hsa_circ_0068631) is up-regulated in ovarian cancer tissues/cells and mainly localized in the cytoplasm. Silencing circ-TFRC suppresses OC proliferation, migration/invasion, tumor growth and lung metastasis by acting as a ceRNA to sponge miR-615-3p and thereby increase IGF2 expression.
Confidence score:

0.7369
Other information
Title:

circ-TFRC downregulation suppresses ovarian cancer progression via miR-615-3p/IGF2 axis regulation.

Journal: Cancer cell international
Published: 2024
PubMed ID: 38678242
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -