| Expression pattern: |
UP |
| Associated gene: |
PRM1, Ago2 |
| Associated microRNA: |
miR-1256, miR-1233 |
| Biological function: |
promotes CRC cell proliferation, migration/invasion and metastasis |
| Molecular mechanism: |
ceRNA sponging of miR-1256 to upregulate PRM1 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
High circANXA4 expression is associated with advanced stage, distant metastasis, reduced overall survival and shorter disease-free survival in CRC patients. |
| Description: |
CircANXA4 is up-regulated in colorectal cancer tissues and cell lines and is associated with advanced stage, distant metastasis, and worse survival. Functionally, circANXA4 promotes CRC cell proliferation and invasion by acting as a ceRNA that sponges miR-1256, thereby increasing PRM1 expression. |
| Confidence score: |
0.848 |