circRNA basic information
circBase ID: hsa_circ_0076691
Name: hsa_circ_RUNX2
Synonym: circ_0076691
Host Gene: RUNX2
Genomic location(hg19): chr6:45459677-45480144:+
Genomic location(hg38): chr6:45491940-45512407:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma / OS
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OS tissue; adjacent non-tumor tissue (ANT)
Cell lines:

MG63; Saos2; 143B; U2OS; hFOB 1.19
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CBX4
Associated microRNA: -
Biological function: unknown
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation
Clinical significance:

-
Description:

circ_0076691 is up-regulated in osteosarcoma samples and cell lines, likely linked to CBX4-mediated transcriptional activation at the RUNX2 locus. The study did not find significant associations with clinical features/prognosis and did not establish a specific functional mechanism for circ_0076691 in OS.
Confidence score:

0.2995
Other information
Title:

Upregulation of circ_0076684 in osteosarcoma facilitates malignant processes by mediating miRNAs/CUX1.

Journal: Journal of orthopaedic surgery and research
Published: 2024
PubMed ID: 38659042
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -