| Expression pattern: |
UP |
| Associated gene: |
CUX1, CBX4 |
| Associated microRNA: |
miR-370-3p, miR-140-3p, miR-193a-5p |
| Biological function: |
promotes OS cell proliferation, migration, invasion and tumor growth |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-370-3p/miR-140-3p/miR-193a-5p to increase CUX1 expression; promotes OS progression via CUX1 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis |
| Clinical significance: |
circ_0076684 expression was significantly associated with tumor size, lung metastasis, Enneking stage, and overall survival time of OS patients |
| Description: |
circ_0076684 is up-regulated in osteosarcoma and promotes malignant phenotypes (proliferation, migration, invasion, and xenograft tumor growth). Mechanistically, it functions as a cytoplasmic ceRNA that sponges miR-370-3p/miR-140-3p/miR-193a-5p to increase CUX1 expression, and its high expression is associated with worse clinical features and prognosis. |
| Confidence score: |
0.7592 |