| Expression pattern: |
DN |
| Associated gene: |
PDE5A-500aa, PIK3IP1, USP14 |
| Associated microRNA: |
- |
| Biological function: |
inhibits ESCC proliferation and metastasis |
| Molecular mechanism: |
encodes PDE5A-500aa which interacts with PIK3IP1 and promotes USP14-mediated de-ubiquitination (K48-linked polyubiquitin at K198) to attenuate PI3K/AKT signaling |
| Biological pathway or process: |
PI3K/AKT (inhibits); proliferation (inhibits); metastasis (inhibits); EMT (inhibits); ubiquitination (inhibits) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Actinomycin D / DRB Stability Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); RNA-seq; Bioinformatics Analysis; Survival Analysis; Clinical Sample Validation; Cohort Study |
| Clinical significance: |
low circPDE5A expression is associated with later clinicopathological stages and poor prognosis; low circPDE5A is an independent prognostic factor in ESCC patients |
| Description: |
circPDE5A is down-regulated in ESCC and acts as a tumor suppressor by inhibiting proliferation, metastasis and EMT. It functions mainly by encoding the peptide PDE5A-500aa, which stabilizes PIK3IP1 via USP14-mediated de-ubiquitination (K48 chain, K198) and thereby suppresses PI3K/AKT signaling. Low circPDE5A is associated with advanced stage and worse prognosis in ESCC patients. |
| Confidence score: |
0.8414 |