| Expression pattern: |
UP |
| Associated gene: |
KLF6 |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation and invasion of thyroid cancer cells |
| Molecular mechanism: |
circ-ABCB10 targets KLF6 and negatively regulates KLF6 expression |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
potential therapeutic target in thyroid cancer |
| Description: |
circ-ABCB10 is up-regulated in thyroid cancer tissues and thyroid cancer cell lines. Functional assays indicate that circ-ABCB10 promotes thyroid cancer cell proliferation and invasion in vitro, at least partly by targeting and negatively regulating KLF6. The study proposes the circ-ABCB10/KLF6 axis as a potential therapeutic target for thyroid cancer. |
| Confidence score: |
0.5732 |