circRNA basic information
circBase ID: -
Name: mmu_circ_Pvt1
Synonym: circ-0005724
Host Gene: Pvt1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0043458
MONDO name: radiation injury
Disease details: ionizing radiation exposure
Disease DO ID:
 -
Disease MeSH ID:
 D011832
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Mouse
Species details: Mus musculus
Tissue specimen:

blood; embryonic mouse brain / brain; primary mouse cortical neurons
Cell lines:

Neuro2a
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: Qki
Associated microRNA: -
Biological function: more stable than linear counterpart; potential long-term biomarker for radiation exposure
Molecular mechanism: circRNA stability increase; prolonged induction after irradiation
Biological pathway or process:

other pathway/process (other)
Detected method:
Q
Validation methods:

divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; In Vivo Animal Model
Clinical significance:

long-term biomarker candidate for radiation exposure (blood, 10 days after whole body irradiation)
Description:

circ-0005724 is a Pvt1-derived circRNA validated as a circular, RNase R-resistant transcript and shown to be stable. It is upregulated after irradiation with prolonged kinetics and increases in blood 10 days post whole-body irradiation, supporting its candidacy as a long-term radiation exposure biomarker.
Confidence score:

0.527
Other information
Title:

Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons.

Journal: Cells
Published: 2019
PubMed ID: 31357500
Study type:

biological research
Data availability: Table S1
Code availability: -