circRNA basic information
circBase ID: hsa_circ_0078607
Name: -
Synonym: circ_0078607
Host Gene: -
Genomic location(hg19): chr6:160819010-160831878:+
Genomic location(hg38): chr6:160397978-160410846:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

SMMC7721/S; Huh7/S; SMMC7721; Huh7
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CDC42EP5, FABP3, NSMF, ADAMTS10, GRB10, F12, IA2, MIA2
Associated microRNA: miR-320b
Biological function: promotes sorafenib resistance; promotes metabolic reprogramming
Molecular mechanism: ceRNA network where circ_0078607 targets miR-320b to regulate downstream mRNAs; network mRNAs enriched in vesicle-mediated transport and linked to TGF-beta signaling activation
Biological pathway or process:

TGF-beta/SMAD (other); ceRNA regulation (other); other pathway/process (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

circ_0078607 is upregulated in sorafenib-resistant HCC cells and is proposed (via a ceRNA network) to target miR-320b, affecting downstream mRNAs including CDC42EP5, FABP3, NSMF, ADAMTS10, GRB10, F12, IA2, and MIA2. Enrichment analysis connects this network to vesicle-mediated transport and TGF-beta signaling, suggesting a role in metabolic reprogramming-related sorafenib resistance.
Confidence score:

0.1768
Other information
Title:

Deciphering the role of non-coding RNAs involved in sorafenib resistance.

Journal: Heliyon
Published: 2024
PubMed ID: 38644890
Study type:

biological research; bioinformatics study
Data availability: available from the corresponding author upon a reasonable request; https://doi.org/10.1016/j.heliyon.2024.e29374
Code availability: -