| Expression pattern: |
DN |
| Associated gene: |
PRCD, MPDU1, LGALS4, NAA10, TGFBR3, SEMA6B, ZNF672, HIST1H1D, WIPF2, RTL8A |
| Associated microRNA: |
miR-27a-5p |
| Biological function: |
promotes sorafenib resistance; promotes metabolic reprogramming; promotes EMT |
| Molecular mechanism: |
ceRNA network where circ_0002874 targets miR-27a-5p to regulate downstream mRNAs; linked to Hippo signaling activation and EMT/metabolic reprogramming |
| Biological pathway or process: |
Hippo/YAP (promotes); EMT (promotes); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_0002874 is downregulated in sorafenib-resistant HCC cells and is placed in a ceRNA network where it targets miR-27a-5p to affect downstream mRNAs. Network-level enrichment links this axis to Hippo signaling activation and to processes related to metabolic reprogramming and EMT that may contribute to sorafenib resistance. |
| Confidence score: |
0.1768 |