circRNA basic information
circBase ID: -
Name: mmu_circ_Pvt1
Synonym: circ-0000604
Host Gene: Pvt1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0043458
MONDO name: radiation injury
Disease details: ionizing radiation exposure
Disease DO ID:
 -
Disease MeSH ID:
 D011832
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Mouse
Species details: Mus musculus
Tissue specimen:

embryonic mouse brain / brain; primary mouse cortical neurons; blood
Cell lines:

Neuro2a
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: Qki
Associated microRNA: -
Biological function: may represent long-term biomarkers for radiation exposure; more stable than linear counterpart
Molecular mechanism: circRNA stability increase; Qki does not regulate Pvt1 circRNA biogenesis in Neuro-2a cells
Biological pathway or process:

other pathway/process (other)
Detected method:
Q
Validation methods:

divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Transfection; In Vivo Animal Model
Clinical significance:

potential long-term biomarker for radiation exposure
Description:

circ-0000604 is a Pvt1-derived circRNA validated by RT-qPCR and RNase R resistance assays. It is induced after ionizing radiation exposure with delayed kinetics and shows increased stability versus the linear transcript, supporting its potential as a longer-term radiation exposure biomarker.
Confidence score:

0.5862
Other information
Title:

Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons.

Journal: Cells
Published: 2019
PubMed ID: 31357500
Study type:

biological research
Data availability: Table S1
Code availability: -