circRNA basic information
circBase ID: -
Name: hsa_circ_ARHGAP10
Synonym: circARHGAP10
Host Gene: ARHGAP10
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm; exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: Non-small-cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

whole blood; serum; serum-derived exosomes; NSCLC tissues; neighboring normal tissues; tumor tissues
Cell lines:

BEAS-2B; A549; H292; 293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: FAM83F, Glut1, LDH, Ago2
Associated microRNA: miR-638
Biological function: Promotes NSCLC cell proliferation, migration, invasion, glycolysis, and in vivo tumor growth; serum-derived exosomes increase circARHGAP10 expression in NSCLC cells.
Molecular mechanism: circARHGAP10 acts as a ceRNA sponge for miR-638 to upregulate FAM83F, thereby promoting proliferation, migration, invasion, and glycolysis of NSCLC cells.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; Western Blot; Bioinformatics Analysis
Clinical significance:

Potential NSCLC diagnostic biomarker and therapeutic target.
Description:

circARHGAP10 is upregulated in NSCLC tissues, cells, serum, and serum-derived exosomes. It promotes NSCLC proliferation, migration, invasion, glycolysis, and xenograft tumor growth by sponging miR-638 and increasing FAM83F expression, suggesting potential biomarker and therapeutic relevance.
Confidence score:

0.7795
Other information
Title:

Serum-Derived Exosomes-Mediated Circular RNA ARHGAP10 Modulates the Progression of Non-Small Cell Lung Cancer Through the miR-638/FAM83F Axis.

Journal: Cancer biotherapy & radiopharmaceuticals
Published: 2022
PubMed ID: 32783691
Study type:

combined biological and clinical study
Data availability: -
Code availability: -