| Expression pattern: |
DN |
| Associated gene: |
E-cadherin, N-cadherin, Vimentin |
| Associated microRNA: |
- |
| Biological function: |
Circ-SMAD7 inhibits GC cell migration, invasion, EMT process, and tumor metastasis in vivo. |
| Molecular mechanism: |
Upregulation of circ-SMAD7 reverses or suppresses the EMT process by increasing E-cadherin and decreasing N-cadherin and Vimentin. |
| Biological pathway or process: |
migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
Circ-SMAD7 could serve as a prospective therapeutic target for GC. |
| Description: |
Circ-SMAD7 is down-regulated in gastric cancer tissues and cell lines. Its upregulation suppresses GC migration, invasion, and in vivo metastasis, likely by reversing the EMT process through increased E-cadherin and decreased N-cadherin and Vimentin. The study suggests circ-SMAD7 may be a prospective therapeutic target for GC. |
| Confidence score: |
0.5414 |