circRNA basic information
circBase ID: hsa_circ_0024353
Name: hsa_circ_APOC3
Synonym: -
Host Gene: APOC3
Genomic location(hg19): chr11:116700623-116703787:+
Genomic location(hg38): chr11:116829907-116833071:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: Prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PCa tissues; normal adjacent prostatic tissues
Cell lines:

PC-3; RWPE-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PDE7B, DMRT2
Associated microRNA: hsa-miR-1234, hsa-miR-1250, hsa-miR-1253, hsa-miR-127-5p, hsa-miR-1286, hsa-miR-183, hsa-miR-198, hsa-miR-324-5p, hsa-miR-331-3p, hsa-miR-338-3p, hsa-miR-339-3p, hsa-miR-370, hsa-miR-486-3p, hsa-miR-503, hsa-miR-578, hsa-miR-580, hsa-miR-605, hsa-miR-1270, hsa-miR-620, hsa-miR-646, hsa-miR-661, hsa-miR-665, hsa-miR-767-3p, hsa-miR-940, hsa-miR-941
Biological function: unknown
Molecular mechanism: Predicted circRNA-miRNA-mRNA interaction (ceRNA network) involving hsa-miR-940/PDE7B and hsa-miR-1253/DMRT2.
Biological pathway or process:

PI3K/AKT (other); HIF-1 signaling (other); p53 signaling (other); cell cycle (other); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; divergent primers PCR; RT-qPCR
Clinical significance:

-
Description:

hsa_circ_0024353 is down-regulated in PC-3 prostate cancer cells versus RWPE-1. Bioinformatics predicts it may act in a circRNA-miRNA-mRNA network by sponging miR-940 and miR-1253 to regulate PDE7B and DMRT2, respectively, with downstream genes enriched in pathways including PI3K-Akt, HIF-1, p53, and cell cycle.
Confidence score:

0.3858
Other information
Title:

Identification of Prostate Cancer-Related Circular RNA Through Bioinformatics Analysis.

Journal: Frontiers in genetics
Published: 2020
PubMed ID: 32922436
Study type:

combined biological and clinical study
Data availability: GSE140927; TCGA
Code availability: -