| Expression pattern: |
UP |
| Associated gene: |
PTMA, Ago2 |
| Associated microRNA: |
miR-370-5p |
| Biological function: |
Promotes NPC cell proliferation, migration, invasion and Warburg effect; inhibits apoptosis. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-370-5p to modulate PTMA expression, supporting glycolysis-related phenotypes. |
| Biological pathway or process: |
glycolysis (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; divergent primers PCR; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
High circCOL1A1 expression is significantly associated with lymph node metastasis and advanced TNM stage in NPC. |
| Description: |
circCOL1A1 (hsa_circ_0044569) is up-regulated in nasopharyngeal carcinoma tissues and NPC cell lines and is mainly localized in the cytoplasm. It promotes proliferation, migration, invasion and glycolysis/Warburg-effect phenotypes and inhibits apoptosis by sponging miR-370-5p to modulate PTMA in a circCOL1A1/miR-370-5p/PTMA axis. High circCOL1A1 expression correlates with lymph node metastasis and advanced TNM stage. |
| Confidence score: |
0.8275 |