| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potentially associated with EC development/malignant progression; higher serum expression associated with worse OS and PFS and with stage, histologic grade, and residual tumor; offers diagnostic value as a circulating biomarker. |
| Molecular mechanism: |
Not mechanistically characterized in this study; evaluated as a circulating diagnostic biomarker and correlated with clinicopathological characteristics and survival. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Sanger Sequencing; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis |
| Clinical significance: |
Serum circEPSTI1 distinguishes EC patients from healthy controls (AUC 0.8351); high serum circEPSTI1 associated with worse PFS and OS and correlated with stage, histologic grade, and residual tumor. |
| Description: |
circEPSTI1 is up-regulated in the serum/plasma of endometrial cancer patients and can discriminate EC from healthy controls by ROC analysis. High serum circEPSTI1 correlates with more aggressive clinicopathological features and predicts worse PFS/OS, supporting its use as a circulating diagnostic/prognostic biomarker (especially combined with MIF). |
| Confidence score: |
0.5918 |