| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-103a-2-5p |
| Biological function: |
Promotes proliferation, migration, and invasion of colorectal cancer cells. |
| Molecular mechanism: |
Targets (sponges) miR-103a-2-5p as a miRNA sponge mechanism in CRC cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay |
| Clinical significance: |
Upregulation was associated with poor differentiation and lymphatic metastasis of CRC. |
| Description: |
hsa_circ_0007142 (derived from DOCK1) is up-regulated in colorectal cancer tissues and in CRC cell lines (HCT-116 and HT-29). It promotes malignant phenotypes (proliferation, migration, invasion) and directly targets miR-103a-2-5p, consistent with a miRNA-sponge/ceRNA-like mechanism; clinically, higher expression associates with poor differentiation and lymphatic metastasis. |
| Confidence score: |
0.7177 |